protect trial prostate cancer

protect trial prostate cancer

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The decrease in cholesterol may reduce the risk of some cancers

Most people know that cholesterol levels can help protect his heart. But new research suggests another potential benefit: lower risk of some cancers.

In fact, total cholesterol, low risk a 60 per cent less than the most aggressive form of prostate cancer and higher levels of good cholesterol (HDL) may protect against lung cancer, the liver and other cancers, according to two studies published this week in the journal Cancer Epidemiology, Biomarkers & Prevention.

That's all quite a change of fortune for the low cholesterol, which in the past has been associated with increased risk of cancer. New studies suggest that low cholesterol does not deserve its bad reputation, earned from a series of studies in the 1980s who said that poor people in cholesterol may be at risk of cancer.

In fact, it can lower cholesterol in people diagnosed with cancer, This means that low cholesterol may be the result – and not a cause – cancer.

In the first study, men with HDL cholesterol above about 55 mg / dl showed a reduction of 11 per cent of the overall risk of cancer, including lung and liver. (Levels of HDL between 40 and 50 are averages for men). The study, conducted by the National Cancer Institute (NCI) researchers who have visited about 29,000 male smokers in Finland for a period 18, is the first to show a relationship between HDL and cancer.

"Very few studies measuring [HDL], and any relationship between HDL and risk cancer overall had not been properly evaluated in order, "said principal author Dr. Demetrius Albanes NCI study, said in an Information Press.

Although the results are new and interesting, more research is needed to confirm a link between HDL cholesterol and reduce the risk of cancer.

"[It's] very recently, the interesting question, but we must do much more research before we have no clear answer, "said Eric Jacobs, an epidemiologist at American Cancer Society, who co-wrote an editorial accompanying the studies. For its part, Albanes said that the results must be confirmed, including in women and nonsmokers.

Initially, Albanes and his colleagues found their results seem to support studies in the 1980s, found that men with low total cholesterol had a higher risk of cancer. The tendency to disappear when we exclude cases of cancer been diagnosed during the first nine years of study. (These men may have had cancer but had not been diagnosed yet.)

In the second study, researchers examined almost 5,500 men aged 55 and over. Men with total cholesterol below 200 mg / dL – range from the National Heart, Lung and Blood Institute considers "desirable" – was about 60 percent lower risk of cancer of high grade cancer prostate cancer, an aggressive type.

"It was a marked reduction, which is not often seen in research of prostate cancer," researcher Elizabeth Platz, a cancer epidemiologist at the Johns Hopkins Bloomberg School of Public Health, told reporters.

Risk reduction has been detected in tumors with high grade and not in less serious cases of prostate cancer – the reason for the Platz and colleagues that in a earlier study, are similar. According to Jacobs, the pattern is not uncommon in studies on prostate cancer. Obesity, for example, is associated with an increased risk of tumors more dangerous, but not with prostate cancer in general, said.

This study was inspired in part by an increasing number of evidence suggesting that statins, which are cholesterol-lowering drugs such as Lipitor, may protect against cancers of high grade prostate cancer. In the current study, however, Platz and her colleagues measured the use of statins and thus were unable to determine if the reduced risk of prostate cancer has been strongly influenced by statins or cholesterol-lowering approaches, rather that lowering cholesterol naturally.

"Our next step … is not to be found in total cholesterol, but also to evaluate the relationship between high HDL and low LDL cholesterol but also to examine whether lower cholesterol rather than cholesterol below the normal state these men may also explain this relationship "said Platz.

More studies, including randomized controlled trials are necessary to explain the relationship between cholesterol and prostate cancer, according to Platz.

Jacobs agreed, noting that the results of the two studies raise important questions. The effect of HDL cholesterol and total cholesterol and cancer risk are "probably the very areas interesting for future research, "he said.

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