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Alkaptonuria â € "Symptoms, Causes and Treatment

Alkaptonuria is an inherited disease that causes the urine becomes black when exposed to air. Alkaptonuria, an accumulation of dark pigment in connective tissues such as cartilage and skin are also characteristic disease. This blue-black pigmentation, usually appears after age 30. People with rheumatoid alkaptonuria overall development, especially in the spine and large joints, from adulthood. Other features of this disorder can include heart problems, kidney stones and prostate stones.

Symptoms
The main symptoms of alkaptonuria are due to the accumulation of acid homogentisic tissue. In the joints causing damage to cartilage, specifically in the spine and lead to back pain in a young age in most cases, but also hip and shoulder. Joint replacement surgery (hip and schoulder) is often necessary for an age relatively young.

Urine in the diapers May darken and become almost black after several hours. However, many people this condition it may not know they have until mid-adulthood, around age 40, when joint disorders and other problems.

Urine in the layer of a baby in May darken and become almost black after several hours. However, many people with this condition in May does not know they have until mid-adulthood, around age 40, when joint and other problems.

Causes
Alkaptonuria is caused by a deficiency of an enzyme called homogentisic acid oxidase (HGAO). Normally, this enzyme plays a crucial stage in the course of the conversion of a chemical, homogentisic acid (HGA), an alternative way to meet the needs of the body. As a normal amount of the missing enzyme HGAO HGA does not decompose and not accumulate in the body. Some are excreted in the urine, and the rest is deposited in body tissues where it is harmful. The result is a change from black-blue tissue including bone, cartilage and skin (also known as ochronosis).

The defect causes the body can not properly break certain proteins (tyrosine and phenylalanine). Therefore, a substance called homogentisic acid accumulates in the skin and other body tissues. The acid leaves the body through urine. The urine becomes dark brown when mixed with air.

Inability to acid to convert the results Maleylacetoacetic homogentisic acid accumulation in the first. Homogentisic acid is then converted to benzoquinone acetic acid and spontaneously polymerized. Deposition polymers in combination with pathophysiological cartilage causes the appearance Arthritis.

Diets low in protein – especially in amino acids, phenylalanine (found in aspartame) and tyrosine – helping to reduce the levels of HGA, thereby reducing the amount of pigment deposited in tissues. Symptoms of alkaptonuria (arthropathy, for example, cardiovascular disease) are treated if possible. Unfortunately, the evolution of the disease remains unchanged, and no cure available.

Treatment
No treatment modality has been clearly demonstrated that the reduction of complications of alkaptonuria. Treatments commonly recommended include dietary restrictions doses of phenylalanine and tyrosine, and the large amount of ascorbic acid (vitamin C). The food restriction may be effective in children, but the benefits in adults have not been demonstrated.

Some patients are protected by high doses of vitamin C. This has been shown to decrease the accumulation of brown pigment in the cartilage and may slow the development Arthritis.

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Something wrong with my pelvis – prostate problem is it possible?

I saw the doctor today because I was burning when urinating. They urine was tested to see if I had an infection or possible kidney stones, but test was negative. Then the doctor took a swab stick and stick the thing in my penis hole and swirling around about 3 times that, as a injury (insert curse word here) and she said that the results The test lasted 5 days. I am a little worried because I wished it was rather infection or stones. Is this a problem with my prostate? And if so, what should I do? The doctor has even mentioned a problem Prostate possible and not think to ask at the time. Any advice? Are there other symptoms that indicate definitely me if my prostate? If Please advise. Thank you. Appreciate the responses with the exception of Tom-Tom, but all modes. You have pain in the area where my pubic hair is above my penis, especially when coughing or urinating. I'll see a urologist.

Sounds like a prostate problem, and probably is. Probably. If you've been rubbing cocaine into the penis, then you should probably leave because a) he will notice and B) if not soon, will wither and fall. It could also be a cancer of the urethra, in which case you'll probably lose anyway. extra sensitivity gives suggests that it may be. Have a nice day.

“What is Urology?” featuring Dr. Vaughan (YourUrologyMD)

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